The Johns Hopkins Center for Microphysioloigcal systems supports studies that focus on the development, validation and application of personalized models of human biology and diseases. We facilitate the design and integration of tissue chip technologies with induced pluripotent stem cell (iPSC) and/or primary tissues derived from patients and healthy donors. Modeling human physiology in physiologically-relevant ‘chips’ enables the detailed study of mechanistic pathways that underlie disease onset, progression, and treatment at previously unattainable granularity. Ultimately, these devices streamline and accelerate preclinical therapy development and facilitate predictions of individual patients’ responsiveness to drugs.

The JHU-MPS Center serves as a development hub to investigators and commercial collaborators in need of humanized preclinical models. Internally, we support teams composed of technology developers and final users to establish the tools needed to generate the preliminary data to apply for NIH funding successfully. Externally, we collaborate with academic and commercial partners to further the field of MPS technologies and their use for preclinical research .

The Center’s mission is supported by two main pillars