Publication highlight: PDMS–PEG Block Copolymer and Pretreatment for Arresting Drug Absorption in Microphysiological Devices

The Kim lab has recently published an article “PDMS–PEG Block Copolymer and Pretreatment for Arresting Drug Absorption in Microphysiological Devices“ in ACS Applied Materials and Interfaces. Absorption of drugs by PDMS is a very well-known problem in the MPS field. As we move towards the use of microphysiological systems for drug screening, easily adoptable methods for preventing drug absorption are necessary. The Kim lab at JHU developed an effective and facile method to prevent the absorption of drugs by utilizing a PDMS–PEG block copolymer additive and drug pretreatment. First, we incorporated a PDMS–PEG block copolymer into PDMS to address its inherent hydrophobicity. Next, we addressed the permeability of PDMS by eliminating the concentration gradient via pretreatment of the PDMS with the drug prior to experimentally testing drug absorption.

read the full manuscript at https://pubs.acs.org/doi/full/10.1021/acsami.2c10669